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Synaptic strengthening through activation of Ca2+-permeable AMPA receptors.
Gu, J G; Albuquerque, C; Lee, C J; MacDermott, A B.
Afiliação
  • Gu JG; Department of Physiology and Cellular Biophysics, Columbia University, New York, 10032, USA.
Nature ; 381(6585): 793-6, 1996 Jun 27.
Article em En | MEDLINE | ID: mdl-8657283
Postsynaptic Ca2+ elevation during synaptic transmission is an important trigger for short- and long-term changes in synaptic strength in the vertebrate central nervous system. The AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate) receptors, a subfamily of glutamate receptors, mediate much of the excitatory synaptic transmission in the brain and spinal cord. It has been shown that a subtype of the AMPA receptor is Ca2+-permeable and is present in the subpopulations of neurons. When synaptically localized, these receptors should mediate postsynaptic Ca2+ influx, providing a trigger for changes in synaptic strength. Here we show that Ca2+-permeable AMPA receptors are synaptically localized on a subpopulation of dorsal horn neurons, and that they provide a synaptically gated route of Ca2+ entry, and that activation of these receptors strengthens synaptic transmission mediated by AMPA receptors. This pathway for postsynaptic Ca2+ influx may provide a new form of activity-dependent modulation of synaptic strength.
Assuntos
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Base de dados: MEDLINE Assunto principal: Sinapses / Cálcio / Receptores de AMPA / Neurônios Idioma: En Ano de publicação: 1996 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Sinapses / Cálcio / Receptores de AMPA / Neurônios Idioma: En Ano de publicação: 1996 Tipo de documento: Article