Synaptic strengthening through activation of Ca2+-permeable AMPA receptors.
Nature
; 381(6585): 793-6, 1996 Jun 27.
Article
em En
| MEDLINE
| ID: mdl-8657283
Postsynaptic Ca2+ elevation during synaptic transmission is an important trigger for short- and long-term changes in synaptic strength in the vertebrate central nervous system. The AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate) receptors, a subfamily of glutamate receptors, mediate much of the excitatory synaptic transmission in the brain and spinal cord. It has been shown that a subtype of the AMPA receptor is Ca2+-permeable and is present in the subpopulations of neurons. When synaptically localized, these receptors should mediate postsynaptic Ca2+ influx, providing a trigger for changes in synaptic strength. Here we show that Ca2+-permeable AMPA receptors are synaptically localized on a subpopulation of dorsal horn neurons, and that they provide a synaptically gated route of Ca2+ entry, and that activation of these receptors strengthens synaptic transmission mediated by AMPA receptors. This pathway for postsynaptic Ca2+ influx may provide a new form of activity-dependent modulation of synaptic strength.
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Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Cálcio
/
Receptores de AMPA
/
Neurônios
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article