HIV-1 Gag protein associates with F-actin present in microfilaments.
Virology
; 220(2): 530-4, 1996 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-8661406
ABSTRACT
Several studies have provided evidence that the cellular cytoskeleton may be involved in the assembly and budding of retroviruses. In fractionation studies of HIV-1-infected CEM cells, the majority of the unprocessed Gag polyprotein cofractionated with the cellular cytoskeleton. In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1.
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Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto de Actina
/
Produtos do Gene gag
/
Actinas
/
HIV-1
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article