LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.
J Exp Med
; 183(4): 1415-26, 1996 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-8666900
ABSTRACT
The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed normal ex vivo CTL function. However, LFA-1-deficient mice did not reject immunogenic tumors grafted into footpads and did not demonstrate priming response against tumor-specific antigen. Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic infection are normal.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Viroses
/
Linfócitos T Citotóxicos
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Integrinas
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Antígeno-1 Associado à Função Linfocitária
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Antígenos CD18
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article