Control of MHC restriction by TCR Valpha CDR1 and CDR2.
Science
; 273(5277): 963-6, 1996 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-8688082
ABSTRACT
Individual T cell receptor (TCR) Valpha elements are expressed preferentially in CD4 or CD8 peripheral T cell subsets. The closely related Valpha3.1 and Valpha3.2 elements show reciprocal selection into CD4 and CD8 subsets, respectively. Transgenic mice expressing site-directed mutants of a Valpha3.1 gene were used to show that individual residues in either the complementarity-determining region 1 (CDR1) or CDR2 were sufficient to change selection from the CD4 subset to the CD8 subset. Thus, the germline-encoded Valpha elements are a major influence on major histocompatibility class complex (MHC) restriction, most likely by a preferential interaction with one or the other class of MHC molecule.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
/
Linfócitos T CD4-Positivos
/
Antígenos de Histocompatibilidade Classe II
/
Receptores de Antígenos de Linfócitos T alfa-beta
/
Linfócitos T CD8-Positivos
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article