Effects of spaceflight on rat peripheral blood leukocytes and bone marrow progenitor cells.
J Leukoc Biol
; 60(1): 37-43, 1996 Jul.
Article
em En
| MEDLINE
| ID: mdl-8699121
ABSTRACT
The white blood cell (WBC) elements and the bone marrow myeloid progenitor cell populations were analyzed to ascertain adaptation to micro-gravity and subsequent readaptation to 1 G in rats flown on the 14-day Spacelab Life Sciences-2 (SLS-2) mission. Bone marrow cells were harvested from one group of rats killed inflight (FD13) and blood was drawn from three other groups at various times. The WBC level was normal on FD14 with the exception of neutrophilia. On FD13, numbers of colony-forming units-granulocyte (CFU-G), CFU-GM, and CFU-M from flight animals were decreased compared with ground controls when incubated with recombinant rat interleukin-3 (rrIL-3) alone or in combination with recombinant human erythropoietin (rhEpo). On recovery (R + 0), flight rats had decreased numbers of total leukocytes and absolute numbers of lymphocytes and monocytes with elevated neutrophils compared with control rats. They had lower numbers of CD4, CD8, CD2, CD3, and B cells in the peripheral blood but no differences in spleen lymphocytes.
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Base de dados:
MEDLINE
Assunto principal:
Voo Espacial
/
Células-Tronco Hematopoéticas
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Linfócitos
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Contagem de Leucócitos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article