Effect of beta-aminopropionitrile on bone mechanical properties.
J Bone Joint Surg Am
; 59(5): 670-2, 1977 Jul.
Article
em En
| MEDLINE
| ID: mdl-873962
ABSTRACT
In vivo beta-aminopropionitrile treatment caused significant changes in the mechanical properties of rat femora. In femora treated with beta-aminopropinitrile as compared with controls, there was a 44 per cent decrease in bone stiffness and a 47 per cent increase in bone deformation to failure. Bone ash was decreased 5 per cent in the treated group. It is likely that the decrease in bone ash was secondary to impaired intermolecular bone-collagen cross-linking, which is a well established consequence of treatment with beta-aminopropionitrile. Thus, beta-aminopropionitrile influences bone mechanical properties directly by impairing collagen cross-linking and indirectly by altering bone-matrix mineralization.
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Base de dados:
MEDLINE
Assunto principal:
Fenômenos Biomecânicos
/
Fêmur
/
Aminopropionitrilo
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article