The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.
Cancer Res
; 56(18): 4244-9, 1996 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-8797599
ABSTRACT
The MUC 1 mucin is expressed on normal breast epithelium and in 90% of breast cancers. We report here that tumor-associated MUC1 is a ligand for intercellular adhesion molecule 1 (ICAM-1). Antibodies to ICAM-1 and to MUC1 inhibited adhesion of human and transfected mouse MUC1-positive cell lines to human umbilical vein endothelial cell monolayers and immobilized recombinant human ICAM-1-immunoglobulin fusion protein. Purified MUC1 pretreatment of recombinant human ICAM-1 was an equally effective inhibitor of adhesion. The interaction between MUC1 and ICAM-1 may be critical to the process of bloodborne metastases in breast cancer.
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Base de dados:
MEDLINE
Assunto principal:
Mama
/
Neoplasias da Mama
/
Endotélio Vascular
/
Molécula 1 de Adesão Intercelular
/
Mucina-1
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article