The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34.
Genomics
; 36(1): 182-4, 1996 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-8812433
ABSTRACT
The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.
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Base de dados:
MEDLINE
Assunto principal:
Sarcosina
/
Cromossomos Humanos Par 9
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Mapeamento Cromossômico
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Erros Inatos do Metabolismo dos Aminoácidos
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Mutação
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article