Selective expression of one c-myc allele in two human myeloma cell lines.
Cancer Res
; 56(19): 4370-3, 1996 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-8813127
ABSTRACT
Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all murine plasmacytoma and human Burkitt's lymphoma tumors and are associated with a high incidence of exon 2 missense mutations and selective expression of the affected allele. Screening nine multiple myeloma cell lines, we identified no exon 2 missense mutations but did identify two lines with single, silent mutations in exon 1 and exon 2, respectively. Each of these informative multiple myeloma cell lines selectively expresses only one c-myc allele despite the apparent absence of chromosomal translocations or DNA rearrangements affecting c-myc.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
/
Éxons
/
Genes myc
/
Mutação Puntual
/
Alelos
/
Mieloma Múltiplo
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article