Inflammatory bowel disease in individuals seropositive for the human immunodeficiency virus.
Eur J Gastroenterol Hepatol
; 8(6): 575-8, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8823573
ABSTRACT
OBJECTIVE:
CD4 lymphocytes mediate disease expression in both human immunodeficiency virus (HIV) infection and inflammatory bowel disease (IBD). Analysis of the clinical course of IBD in HIV-seropositive individuals may elucidate aspects of the role of CD4 lymphocytes in the pathogenesis of these conditions.DESIGN:
A retrospective case series study. PATIENTS Diagnostic coding for IBD and pharmacy records for 5-aminosalicylic acid compounds and rectal steroid preparations were examined for all HIV-seropositive subjects attending the Chelsea and Westminster Hospitals between January 1988 and December 1993. Eight HIV-seropositive individuals with a confirmed diagnosis of IBD were identified.SETTING:
HIV/Genitourinary medicine (GUM) units. MAIN OUTCOMEMEASURES:
Change in CD4 count.RESULTS:
Four subjects with an intact colon had a decline in CD4 count of 85 cells/mm3/year, four patients undergoing colectomy had a subsequent rise of four cells/mm3/year and eight case matched controls had a decline of 47 cells/mm3/year. Acute exacerbations of IBD did not cause a significant change in CD4 count. There were no exacerbations of IBD in patients with a CD4 count below 200 cells/mm3.CONCLUSION:
HIV infection may influence the pathogenesis of IBD. A chronically inflamed colon may accelerate CD4 cell depletion which is reversed by colectomy.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Linfócitos T CD4-Positivos
/
HIV
/
Soropositividade para HIV
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article