Dihydroxanthopterinuria in phenylketonuria and lethal hyperphenylalaninemia patients.
Clin Chim Acta
; 78(3): 417-23, 1977 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-884867
ABSTRACT
7,8-Dihydroxanthopterin in identified in urine from phenylketonuria and lethal hyperphenylalaninemia patients. Because 7,8-dihyroxanthopterin is readily oxidised to xanthopterin, most of the characterisation was performed on xanthopterin. This finding indicates a gross disturbance of tetrahydrobiopterin metabolism in these patients. 7,8-dihydroxanthopterin or a related pterin may play a role in the pathogenesis of neurological symptoms in phenylketonuria and lethal hyperphenylalaninemia.
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Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Fenilcetonúrias
/
Xantopterina
/
Erros Inatos do Metabolismo dos Aminoácidos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article