Design of novel cholecystokinin-B receptor ligands based on the 'double-ring system' approach.
Regul Pept
; 65(1): 11-4, 1996 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-8876030
ABSTRACT
A structurally novel series of cholecystokinin-B (CCK-B) receptor ligands has been designed and synthesized based on the 'double ring system' theory of receptor recognition. Compounds 2b-cis and 2g-cis from this 1-amino-2-benzyltetralin series show modest CCK-B receptor affinity, with IC50 values of 48.5 nM and 39.0 nM, respectively. The results are discussed in the context of ongoing efforts to identify the CCK-B receptor binding site for nonpeptide ligands.
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Base de dados:
MEDLINE
Assunto principal:
Receptores da Colecistocinina
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article