3-Carboxy-20-keto steroids are dual uncompetitive inhibitors of human steroid 5 alpha-reductase types 1 and 2.
Bioorg Med Chem
; 4(9): 1481-5, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8894105
ABSTRACT
Steroidal 3-carboxy-20-ketones have been prepared within two structural series, the androsta-3,5-dienes and the estra-1,3,5-trienes, as potential inhibitors of types 1 and 2 steroid 5 alpha-reductase, the enzyme activity responsible for the final step in biosynthesis of dihydrotestosterone. These compounds are shown to be potent uncompetitive inhibitors of both human recombinant enzyme activities, defining a novel class of dual steroid 5 alpha-reductase inhibitors.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
/
Estrenos
/
Inibidores de 5-alfa Redutase
/
Androstadienos
/
Cetoácidos
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article