Inflammatory bowel disease and the X chromosome.
QJM
; 89(9): 713-8, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8917748
A review of documented cases demonstrates a significant association of Turner's syndrome with Crohn's disease and ulcerative colitis; this association relates particularly to genetic constitutions comprising an abnormal rather than an absent X chromosome. The karyotype 46XiXq, in pure or mosaic form, appears to be a significant susceptibility factor for inflammatory bowel disease. This karyotype often gives rise to relatively weak phenotypic characteristics of Turner's syndrome, which may be overlooked in short females with inflammatory bowel disease. The association of inflammatory bowel disease with Turner's syndrome may reflect the presence on the X chromosome of genes involved in disease pathogenesis. Linkage analysis studies, involving microsatellite markers on the X chromosome, are being performed.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Turner
/
Cromossomo X
/
Doenças Inflamatórias Intestinais
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article