Immunomodulating ability of galactoside-specific lectin standardized and depleted mistletoe extract.
Arzneimittelforschung
; 45(11): 1240-2, 1995 Nov.
Article
em En
| MEDLINE
| ID: mdl-8929248
ABSTRACT
Commercially available mistletoe extract standardized for the galactoside-specific lectin (ML-1; Eurixor) and a chromatographically ML-1-depleted preparation (same charge no. and composition of remaining components) were tested for their immunomodulating potency. In BALB/c-mice, regular subcutaneous administration of the optimal immunomodulating dosage (1 ng ML-1/kg body weight) could be shown to induce no influence on spleen weight, a non-significant increase of thymus weight, a significant increase of thymocyte, peritoneal macrophage, peripheral blood leukocyte, lymphocyte and monocyte and monocyte counts, and a significant decrease of peripheral blood granulocyte counts. Administration of analogue volumes (concentrations) of ML-1-depleted extract, however, did not induce any immunopotentiation. Accordingly, it may be assumed, that the galactoside-specific lectin (ML-1) represents the main immunomodulating component in commercially available mistletoe extracts.
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Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Erva-de-Passarinho
/
Adjuvantes Imunológicos
/
Galactosídeos
/
Lectinas
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article