Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta.
J Exp Med
; 184(6): 2079-84, 1996 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-8976164
ABSTRACT
The pre-B cell receptor is a key checkpoint regulator in developing B cells. Early events that are controlled by the pre-B cell receptor include positive selection for cells express membrane immunoglobulin heavy chains and negative selection against cells expressing truncated immunoglobulins that lack a complete variable region (D mu). Positive selection is known to be mediated by membrane immunoglobulin heavy chains through Ig alpha-Ig beta, whereas the mechanism for counterselection against D mu has not been determined. We have examined the role of the Ig alpha-Ig beta signal transducers in counterselection against D mu using mice that lack Ig beta. We found that D mu expression is not selected against in developing B cells in Ig beta mutant mice. Thus, the molecular mechanism for counterselection against D mu in pre-B cells resembles positive selection in that it requires interaction between mD mu and Ig alpha-Ig beta.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Região Variável de Imunoglobulina
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Linfócitos B
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Cadeias alfa de Imunoglobulina
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Cadeias Pesadas de Imunoglobulinas
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Cadeias mu de Imunoglobulina
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article