A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity.
Neuroreport
; 7(15-17): 2529-32, 1996 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-8981417
ABSTRACT
A 22 kDa fragment of apoE containing a putative cytotoxi domain was identified in postmortem human brain tissue and fresh CSF. This fragment is apparently equivalent to the major apoE thrombin cleavage product. In vitro toxicity assays demonstrate that the corresponding fragment derived from recombinantly expressed human apoE is toxic to primary neurons in culture and that the E4-derived fragment is significantly more toxic than the fragment derived from the E3 isoform. These results suggest that proteolytic fragments of apoE may play a direct role in the pathology associated with AD and other diseases in which apoE has been implicated.
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Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Encéfalo
/
Trombina
/
Contagem de Células
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article