Inner ear defects induced by null mutation of the isk gene.
Neuron
; 17(6): 1251-64, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-8982171
ABSTRACT
The isk gene is expressed in many tissues. Pharmacological evidence from the inner ear suggests that isk mediates potassium secretion into the endolymph. To examine the consequences of IsK null mutation on inner ear function, and to produce a system useful for examining the role(s) IsK plays elsewhere, we have produced a mouse strain that carries a disrupted isk locus. Knockout mice exhibit classic shaker/waltzer behavior. Hair cells degenerate, but those of different inner ear organs degenerate at different times. Functionally, we show that in mice lacking isk, the strial marginal cells and the vestibular dark cells of the inner ear are unable to generate an equivalent short circuit current in vitro, indicating a lack of transepithelial potassium secretion.
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Base de dados:
MEDLINE
Assunto principal:
Canais de Potássio
/
Canais de Potássio de Abertura Dependente da Tensão da Membrana
/
Genes
/
Orelha Interna
/
Mutação
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article