MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes.
Cancer Res
; 57(1): 117-22, 1997 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-8988051
ABSTRACT
Fifty-six patients with de novo acute myeloid leukemia M4/M5 subtypes were studied for rearrangements of the mixed lineage leukemia gene, MLL (also called HRX, Htrx-1, or ALL-1). Ten patients (18%) showed rearrangements of the MLL gene, 9 in a major breakpoint cluster region within a centromeric 8.3-kb BamHI fragment, whereas rearrangement in one patient was the result of a direct tandem duplication of exons 2-6 of MLL. Analysis of sequences at the duplication junction revealed that the points of MLL fusion within introns 6 and 1 both lie within Alu elements. This suggests the involvement of Alu repeat mediated homologous recombination in MLL self fusion. For the 10 rearranged samples, cytogenetics analysis revealed a normal karyotype in 3, and 3 had abnormalities other than 11q23. Survival analysis of patients revealed no difference between those with rearrangement of MLL and those showing the germ-line configuration.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 11
/
Rearranjo Gênico
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Leucemia Mielomonocítica Aguda
/
Leucemia Monocítica Aguda
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Child
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Child, preschool
/
Female
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Humans
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Infant
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article