[Lipid derivatives of sarcolysin, methotrexate and rubomycin]. / Lipidnye proizvodnye sarkolizina, metotreksata i rubomitsina]

ABSTRACT

To change the pharmacokinetic properties of the known antitumor agents sarcolysine, rubomycin, and methotrexate, their lipid derivatives were synthesized with the residues of rac-1,2-dioleoylglycerol and heptadecyl alcohol. An ether lipid analog, 3-sarcolysyl 2-methyl-1-octadecyl-sn-glycerol, with the lipid moiety being itself an antineoplastic agent was also obtained.