Intravenous immunoglobulin treatment in therapy-resistant epidermolysis bullosa acquisita.
J Am Acad Dermatol
; 36(2 Pt 2): 331-5, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9039213
ABSTRACT
Epidermolysis bullosa acquisita is an uncommon autoimmune bullous disease of the skin and mucous membranes. It is chronic, disabling, and difficult to treat. We describe a case of severe epidermolysis bullosa acquisita of 7 years' duration that had been treated with azathioprine, corticosteroids, chlorambucil, plasma exchanges, cyclophosphamide, cyclosporine, and colchicine without any lasting effect. Seven cycles of treatment were administered with immunoglobulin given intravenously at a low dose, 40 mg/kg body weight daily for 5 days. The patient was free of disease for 10 months after the initiation of therapy. We suggest that low-dose regimens of immunoglobulins may be as effective in this disease as the high-dose regimens suggested in the literature, and at much lower cost.
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Base de dados:
MEDLINE
Assunto principal:
Epidermólise Bolhosa Adquirida
/
Imunoglobulinas Intravenosas
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article