Identification of an epitope derived from human proteolipid protein that can induce autoreactive CD8+ cytotoxic T lymphocytes restricted by HLA-A3: evidence for cross-reactivity with an environmental microorganism.
J Neuroimmunol
; 73(1-2): 7-14, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9058754
ABSTRACT
The demyelination process that occurs in the central nervous system (CNS) of patients with multiple sclerosis (MS) is in part due to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. In this study, we have identified a peptide sequence derived from the CNS-specific myelin protein proteolipid protein (PLP) which could bind to HLA-A3 and induce a HLA-A3-restricted CD8+ CTL response from HLA-A3+ donors. These PLP peptide-specific CTL could lyse HLA-A3+ target cells pulsed with a homologous peptide derived from the CRM1 protein of Saccharomyces cerevisae. These findings demonstrate the immunogenic potential of a PLP-derived peptide for generation of autoreactive HLA-A3-restricted CD8+ CTL, and further show that these CTL can be activated by a peptide derived from a common environmental microorganism.
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Base de dados:
MEDLINE
Assunto principal:
Apoproteínas
/
Linfócitos T Citotóxicos
/
Autoimunidade
/
Antígeno HLA-A3
/
Receptores Citoplasmáticos e Nucleares
/
Linfócitos T CD8-Positivos
/
Proteína Proteolipídica de Mielina
/
Carioferinas
/
Epitopos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article