Expression of the microfilarial sheath protein 2 (shp2) of the filarial parasites Litomosoides sigmodontis and Brugia malayi.
Exp Parasitol
; 85(3): 241-8, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9085921
ABSTRACT
The microfilarial sheaths of the filarial parasites Brugia malayi, Brugia pahangi, and Litomosoides sigmodontis consist of several parasite proteins, probably ranging between 7 and 10. The gene encoding sheath protein 2 (shp2), which is the object of this study, is transcribed in embryos and in the uterine epithelium; at least in B. malayi, it is translated in both tissues. Apparently, shp2 is synthesized as a monomer, exported by the respective cells, and integrated into the microfilarial sheath. In the sheath, it exists as a highly polymerized molecule cross-linked by cysteine formation and other covalent bonds, presumably epsilon-(gamma-glutamyl)-lysine links.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Helminto
/
Brugia Malayi
/
Filarioidea
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article