Assessment of reproductive disorders and birth defects in communities near hazardous chemical sites. I. Birth defects and developmental disorders.
Reprod Toxicol
; 11(2-3): 223-30, 1997.
Article
em En
| MEDLINE
| ID: mdl-9100297
ABSTRACT
Members of the workgroup on birth defects and developmental disorders discussed methods to assess structural anomalies, genetic changes and mutations, fetal and infant mortality, functional deficits, and impaired fetal and neonatal growth. Tier 1 assessments for all five adverse reproductive outcomes consist of questionnaires and reviews of medical records rather than laboratory testing of biologic specimens. The work-group members noted a role for neurodevelopmental testing and for limited genetic studies, such as karyotyping in Tier 2 assessments. Emerging methodologies to identify chromosomal aberrations, DNA adducts, and repair inhibition were reserved for Tier 3.
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Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Anormalidades Congênitas
/
Resíduos Perigosos
/
Deficiências do Desenvolvimento
/
Exposição Ambiental
/
Morte Fetal
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Child, preschool
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article