Effects of OG-VI, a nucleoside-nucleotide mixture, on ischemic myocardial metabolism in dogs.
Coron Artery Dis
; 8(1): 39-43, 1997 Jan.
Article
em En
| MEDLINE
| ID: mdl-9101121
ABSTRACT
BACKGROUND:
OG-VI is a solution composed of 30 mmol/l inosine, 30 mmol/l sodium 5'-guanylate, 30 mmol/l cytidine, 22.5 mmol/l uridine, and 7.5 mmol/l thymidine, which is known to improve myocardial stunning.OBJECTIVE:
To study the effect of OG-VI on myocardial energy and carbohydrate metabolism during ischemia.METHODS:
Ischemia was induced in pentobarbital-anesthetized open-chested dogs for 3 min by left anterior descending coronary artery ligation. Saline, 1.2 mmol/kg per min OG-VI, or 12 mmol/kg per min OG-VI was infused at 0.1 ml/kg per min, starting 30 min before the onset of ischemia. The myocardium was extracted 3 min after the onset of ischemia, and used to determine the tissue levels of energy and carbohydrate metabolites.RESULTS:
Ischemia decreased the levels of ATP and fructose 1,6 diphosphate significantly, and increased those of AMP, glucose 6 phosphate, fructose 6 phosphate and lactate. OG-VI infusion preserved the adenine nucleotide levels significantly in 3 min ischemic hearts, and attenuated the ischemia-induced alteration of carbohydrate metabolism.CONCLUSION:
OG-VI may improve the myocardial metabolic derangement induced by ischemia.
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Base de dados:
MEDLINE
Assunto principal:
Cardiotônicos
/
Isquemia Miocárdica
/
Miocárdio
/
Nucleosídeos
/
Nucleotídeos
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article