Pharmacokinetics and tolerance of vinorelbine in elderly patients with metastatic breast cancer.
Eur J Cancer
; 33(2): 301-3, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9135505
ABSTRACT
25 patients older than 65 years with metastatic breast cancer were treated with vinorelbine 30 mg/m2 i.v. days 1 and 8 every 3 weeks; the pharmacokinetics were studied in 10 of them. Vinorelbine showed a large apparent volume of distribution (mean 23.4 l/kg), a long terminal half-life (mean 26.2 h) and a large systemic clearance rate (mean 1.2 l/kg). These results are similar to those reported in younger patients. No correlation has been found between toxicity, age and drug exposure. We observed 6 partial responses out of 20 evaluable patients despite a relatively low mean dose intensity (67%). Severe neutropenia occurred in 37% of the patients; other side-effects were acceptable. This study does not provide a pharmacokinetic rationale for reducing the dosage of vinorelbine in selected elderly patients.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Vimblastina
/
Neoplasias da Mama
/
Antineoplásicos Fitogênicos
Limite:
Aged
/
Aged80
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article