Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity.
J Neuroimmunol
; 76(1-2): 132-8, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9184642
ABSTRACT
Human microglia constitute the primary residential antigen presenting cells (APCs) in the central nervous system (CNS) and have the capacity of activating myelin reactive T-cells. T-cell activation requires two signals first is the interaction of the T-cell receptor with the MHC-antigen complex and, secondly, contact of the CD28/CTLA4 T-cell surface molecules with the B7 family of costimulatory molecules on the APCs. We have previously shown high expression of B7.1 in early multiple sclerosis (MS) plaques, suggesting that acute T-cell-mediated CNS inflammation may require local B7.1 upregulation. We have now examined the expression of B7.1 and B7.2 costimulatory molecules on resting ex-vivo human microglia isolated directly from biopsy specimens. We found constitutive expression of B7.2 but not B7.1 on resting microglia, suggesting that B7.2 expression may lead to downregulation of pro-inflammatory Th1 T-cell responses in the normal brain.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Autoimunidade
/
Microglia
/
Antígeno B7-1
Limite:
Adolescent
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article