Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.
Science
; 276(5320): 1848-50, 1997 Jun 20.
Article
em En
| MEDLINE
| ID: mdl-9188528
ABSTRACT
The avian sarcoma virus 16 (ASV 16) is a retrovirus that induces hemangiosarcomas in chickens. Analysis of the ASV 16 genome revealed that it encodes an oncogene that is derived from the cellular gene for the catalytic subunit of phosphoinositide 3-kinase (PI 3-kinase). The gene is referred to as v-p3k, and like its cellular counterpart c-p3k, it is a potent transforming gene in cultured chicken embryo fibroblasts (CEFs). The products of the viral and cellular p3k genes have PI 3-kinase activity. CEFs transformed with either gene showed elevated levels of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and activation of Akt kinase.
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Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Transformação Celular Neoplásica
/
Transformação Celular Viral
/
Fosfotransferases (Aceptor do Grupo Álcool)
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Vírus do Sarcoma Aviário
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article