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Effect of a selective 5-HT3 receptor agonist on gastric motility in fasted and fed dogs.
Nagakura, Y; Ito, H; Kamato, T; Nishida, A; Miyata, K.
Afiliação
  • Nagakura Y; Pharmacological Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd., Tsukuba, Ibaraki, Japan. nagakura@yamanouchi.co.jp
Eur J Pharmacol ; 327(2-3): 189-93, 1997 May 30.
Article em En | MEDLINE | ID: mdl-9200559
The effect of m-chlorophenylbiguanide, a selective 5-HT3 receptor agonist, on gastric antral motility was investigated in conscious dogs with a force transducer implanted chronically. m-Chlorophenylbiguanide (0.1-1 mg/kg i.v.) dose dependently enhanced antral motility in the fasted state, and the amplitude of m-chlorophenylbiguanide (1 mg/kg i.v.)-induced antral contractions reached the level of natural phase III contractions. In contrast, m-chlorophenylbiguanide reduced the amplitude of antral contractions in the fed state. A selective 5-HT3 receptor antagonist, ramosetron (0.0003-0.03 mg/kg i.v.), inhibited both effects of m-chlorophenylbiguanide. m-Chlorophenylbiguanide (1 mg/kg i.v.)-induced contractions were inhibited by atropine (0.03 or 0.1 mg/kg i.v.). These results indicate that pharmacological activation of 5-HT3 receptors has opposite effects on canine gastric antral motility in the fasted and in the fed state, being stimulatory and inhibitory, respectively. The stimulatory effect seems to be mediated mainly via the release of acetylcholine.
Assuntos
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Base de dados: MEDLINE Assunto principal: Estômago / Benzimidazóis / Biguanidas / Agonistas do Receptor de Serotonina / Motilidade Gastrointestinal Limite: Animals Idioma: En Ano de publicação: 1997 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Estômago / Benzimidazóis / Biguanidas / Agonistas do Receptor de Serotonina / Motilidade Gastrointestinal Limite: Animals Idioma: En Ano de publicação: 1997 Tipo de documento: Article