Tailoring cAMP-signalling responses through isoform multiplicity.
Trends Biochem Sci
; 22(6): 217-24, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9204709
ABSTRACT
Multiple forms of cAMP phosphodiesterases (PDE), adenylate cyclase and protein kinase A (PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for its dynamic adjustment. Multiple forms of these enzymes confer spatial and temporal characteristics on cAMP signalling so as to affect compartmentalised responses within a single cell type. The ability to breach the PKA activation threshold can depend upon either or both the activation of adenylate cyclase and inhibition of specific PDE isoforms.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Adenilil Ciclases
/
Proteínas Quinases Dependentes de AMP Cíclico
/
AMP Cíclico
/
3',5'-AMP Cíclico Fosfodiesterases
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article