Control of filament formation in Candida albicans by the transcriptional repressor TUP1.
Science
; 277(5322): 105-9, 1997 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-9204892
ABSTRACT
The pathogenic yeast Candida albicans regulates its cellular morphology in response to environmental conditions. Ellipsoidal, single cells (blastospores) predominate in rich media, whereas filaments composed of elongated cells that are attached end-to-end form in response to starvation, serum, and other conditions. The TUP1 gene, which encodes a general transcriptional repressor in Saccharomyces cerevisiae, was isolated from C. albicans and disrupted. The resulting tup1 mutant strain of C. albicans grew exclusively as filaments under all conditions tested. TUP1 was epistatic to the transcriptional activator CPH1, previously found to promote filamentous growth. The results suggest a model where TUP1 represses genes responsible for initiating filamentous growth and this repression is lifted under inducing environmental conditions.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Candida albicans
/
Proteínas Fúngicas
/
Proteínas Nucleares
/
Proteínas de Saccharomyces cerevisiae
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article