Molecular characterization of attenuated Junin virus strains.
J Gen Virol
; 78 ( Pt 7): 1605-10, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9225036
ABSTRACT
The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Vírus Junin
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article