Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen.
Nucl Med Biol
; 21(1): 9-15, 1994 Jan.
Article
em En
| MEDLINE
| ID: mdl-9234259
ABSTRACT
Ten patients with colorectal cancer metastases received 125I-B72.3 and 131I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumorserum ratios of 131I-CC49 were better than those of 125I-B72.3 (P < 0.01 at 1 mg; P = 0.05 at 20 mg; P < 0.01 at both doses). All known lesions > or = 1 cm in diameter were visualized at the 20 mg dose. There was no difference in absolute tumor uptake of 125I-B72.3 or 131I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas
/
Neoplasias Colorretais
/
Imunoconjugados
/
Radioisótopos do Iodo
/
Anticorpos Monoclonais
/
Antígenos de Neoplasias
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article