Long-term complete remission of melanoma liver metastases after intermittent intra-arterial cisplatin chemotherapy and surgery.
Eur J Surg Oncol
; 23(3): 270-4, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9236905
ABSTRACT
This paper presents the case of a female patient with liver metastases of a malignant melanoma showing complete remission after 10 courses of regional, intra-arterial chemotherapy with cisplatin. The drug was administered as continuous infusion for 5 days. The daily dosage amounted to 30 mg/m2. The interval between courses was 6 weeks. Nausea and vomiting were seen after each course, while pathological serum creatinine levels only appeared after the eighth course. The only lesion in the liver still visible on CT scan after chemotherapy was removed by left hemihepatectomy. Meticulous histological examination revealed a big focus of necrotic tissue without any tumour cells. At the time of publication the patient is alive and disease-free over 9 years later.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Cisplatino
/
Neoplasias Hepáticas
/
Melanoma
/
Antineoplásicos
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article