Habutobin splits the Arg16-Gly17 bond in the A alpha chain of rabbit fibrinogen.
Thromb Haemost
; 77(6): 1127-8, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9241744
ABSTRACT
We reported previously that habutobin, a thrombin-like enzyme from Trimeresurus flavoviridis venom, clotted only rabbit fibrinogen, whereas human, monkey, bovine, dog, rat and guinea-pig fibrinogens were unaffected. In the present study, we investigated the cleavage site of the rabbit A alpha chain by habutobin. The fibrinopeptide released by habutobin was identical to the fibrinopeptide A released by thrombin, and its amino acid sequence corresponded to A alpha 1-16 of rabbit fibrinogen. It was clarified therefore that habutobin cleaves the Arg16-Gly17 bond in the A alpha chain of rabbit fibrinogen.
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Base de dados:
MEDLINE
Assunto principal:
Fibrinogênio
/
Serina Endopeptidases
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article