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Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.
Amos, C I; Bali, D; Thiel, T J; Anderson, J P; Gourley, I; Frazier, M L; Lynch, P M; Luchtefeld, M A; Young, A; McGarrity, T J; Seldin, M F.
Afiliação
  • Amos CI; Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Cancer Res ; 57(17): 3653-6, 1997 Sep 01.
Article em En | MEDLINE | ID: mdl-9288765
Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.
Assuntos
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Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 19 / Síndrome de Peutz-Jeghers / Mapeamento Cromossômico Limite: Female / Humans / Male Idioma: En Ano de publicação: 1997 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 19 / Síndrome de Peutz-Jeghers / Mapeamento Cromossômico Limite: Female / Humans / Male Idioma: En Ano de publicação: 1997 Tipo de documento: Article