Opioids potentiate transmitter release from SK-N-SH human neuroblastoma cells by modulating N-type calcium channels.
Brain Res
; 764(1-2): 277-82, 1997 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-9295225
Opioids induce dual (inhibitory and excitatory) regulation of depolarization-evoked [3H]dopamine release in SK-N-SH cells through either mu or delta receptors. The potentiation of dopamine release by opioid agonists is mediated by N-type voltage-dependent calcium channels and does not involve Gi/Go proteins. Removal of the excitatory opioid effect by blockade with omega-conotoxin, an N-channel antagonist, reveals the inhibitory effect of opioids on release, thus suggesting that both modulatory effects of opioids are exerted in parallel.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Canais de Cálcio
/
Peptídeos Opioides
/
Neurotransmissores
/
Neuroblastoma
Limite:
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article