Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder.
Am J Med Genet
; 74(5): 504-6, 1997 Sep 19.
Article
em En
| MEDLINE
| ID: mdl-9342201
ABSTRACT
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Transtorno Bipolar
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Serotonina
/
Receptores de Serotonina
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article