Fever: effect of drug-induced antipyresis on survival.
Science
; 193(4249): 237-9, 1976 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-935867
ABSTRACT
To determine whether the prevention of fever affects the survival of an animal infected with pathogenic bacteria, lizards (Dipsosaurus dorsalis) were infected with live Aeromonas hydrophila and received varying doses of sodium salicylate, an antipyretic drug. Twelve lizards received identical injections of bacteria along with a nontoxic dose of sodium salicylate; five animals increased their mean body temperature at least 0.6 degrees C and survived the week, whereas seven did not develop a fever and died within 3 days. These data indicate that in these lizards the prevention of fever by use of an antipyretic drug such as sodium salicylate increases the mortality rate from bacterial infection.
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Base de dados:
MEDLINE
Assunto principal:
Salicilato de Sódio
/
Febre
Limite:
Animals
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article