Capillary electrophoresis with electrospray mass spectrometry detection for low-molecular-mass compounds.
J Chromatogr A
; 781(1-2): 99-105, 1997 Sep 26.
Article
em En
| MEDLINE
| ID: mdl-9368381
ABSTRACT
Mass spectrometry (MS) detection using electrospray ionization (ESI) has been explored for the separation by capillary electrophoresis (CE) of a number of sample mixtures containing low-molecular-mass species. Optimal sheath liquid composition has been determined using a peptide mixture in which femtomolar quantities of analyte were easily observed. Effects of CE buffer choice were studied in detail. Also, a separation of basic drugs in cough syrup has been successfully detected by ESI-MS. Using negative ionization, a mixture of alkyl sulfonates and a mixture of food dyes were analyzed. All components were easily resolved and identified by molecular weight.
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Base de dados:
MEDLINE
Assunto principal:
Antitussígenos
/
Peptídeos
/
Espectrometria de Massas
/
Alcanossulfonatos
/
Eletroforese Capilar
/
Corantes
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article