HL 752: a potent and long-acting antispasmodic agent.
Bioorg Med Chem
; 5(7): 1381-7, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9377098
ABSTRACT
Ester analogues of methyl-2-(4-(2-piperidinoethoxy)benzoyl)-benzoate hydrochloride (pitofenone) (2) were prepared with an aim to find a more potent and metabolically stable antispasmodic compound. The compounds were evaluated for their in vitro and in vivo antispasmodic activity, and stability to in vitro enzymatic hydrolysis. Of the compounds synthesised, HL 752 (21) showed the most potent and long-lasting antispasmodic activity and was selected as the candidate for clinical development.
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Base de dados:
MEDLINE
Assunto principal:
Parassimpatolíticos
/
Piperidinas
/
Benzoatos
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article