Effect of L-aspartyl-L-phenylalanine methyl ester on leukotriene biosynthesis in macrophage cells.
Prostaglandins Leukot Essent Fatty Acids
; 57(3): 331-3, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9384524
Macrophage cells treated with L-aspartyl-L-phenylalanine methyl ester (aspartame) produced leukotrienes and other arachidonic acid metabolites. Leukotriene C4, leukotriene B4, and 15-hydroxyeicosatetraenoic acid were the major metabolites detected. The aspartame-treated macrophage cell cultures produced three times as much arachidonic acid metabolites as did the untreated control cell cultures. Leukotriene C4 was produced in the largest amount by the aspartame-treated cells.
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Base de dados:
MEDLINE
Assunto principal:
Aspartame
/
Leucotrienos
/
Macrófagos Peritoneais
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article