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Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.
Lovell, M A; Ehmann, W D; Mattson, M P; Markesbery, W R.
Afiliação
  • Lovell MA; Department of Chemistry, Sanders-Brown Center on Aging, University of Kentucky, Lexington 40536-0230, USA.
Neurobiol Aging ; 18(5): 457-61, 1997.
Article em En | MEDLINE | ID: mdl-9390770
4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD), we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.
Assuntos
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Base de dados: MEDLINE Assunto principal: Líquidos Corporais / Inibidores de Cisteína Proteinase / Ventrículos Cerebrais / Aldeídos / Doença de Alzheimer Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1997 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Líquidos Corporais / Inibidores de Cisteína Proteinase / Ventrículos Cerebrais / Aldeídos / Doença de Alzheimer Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1997 Tipo de documento: Article