Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor.
J Neuroimmunol
; 79(2): 148-54, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9394787
We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results suggest: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development.
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Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Receptores CXCR4
/
Embrião de Mamíferos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article