Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes.
FEBS Lett
; 417(3): 301-6, 1997 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-9409738
ABSTRACT
The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38-K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56(lck). Inhibition of src-like kinases inhibits Rac1 as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56(lck) and Rac1 to JNK/p38-K.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Ativação Linfocitária
/
Linfócitos T
/
Transdução de Sinais
/
Antígenos CD40
/
Proteínas Quinases Ativadas por Mitógeno
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article