Seroprevalence of hepatitis A virus and Helicobacter pylori infections in the general population of a developed European country (the San Marino study): evidence for similar pattern of spread.
Eur J Gastroenterol Hepatol
; 9(11): 1081-4, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9431898
ABSTRACT
OBJECTIVE:
To evaluate the role of faecal-oral transmission in the spread of Helicobacter pylori.DESIGN:
A cross-sectional comparison of the patterns of hepatitis A and H. pylori seropositivity.METHODS:
At interview, blood samples and questionnaire data were collected from a random sample of 1528 healthy subjects aged 20-85 years from the Republic of San Marino. Serum samples from each subject were then tested for anti-H. pylori and anti-hepatitis A antibodies.RESULTS:
Overall, 529 of 670 H. pylori-seropositive subjects (78.9%) and 460 of 858 H. pylori-seronegative subjects (53.6%) were hepatitis A seropositive (P<0.01; odds ratio=3.2; confidence interval 95%=2.6-4.1). This association remained after adjustment by a multiple logistic regression analysis for the confounding effect of age and length of schooling, as surrogate for socio-economic status (OR=2.0; CI 95%=1.3-3.3). The age-specific prevalence curves for H. pylori and hepatitis A infections showed a parallel increase by age, although to a lesser extent for H. pylori.CONCLUSION:
These findings provide evidence that in the community studied H. pylori may have spread in a manner similar to that of hepatitis A.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Infecções por Helicobacter
/
Hepatite A
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article