Mitochondrial sequence variants in patients with schizophrenia.
Eur J Hum Genet
; 5(6): 406-12, 1997.
Article
em En
| MEDLINE
| ID: mdl-9450186
ABSTRACT
To investigate whether mitochondrial mutations underly susceptibility to schizophrenia, we sequenced the mtDNAs of two unrelated Swedish patients with schizophrenia and low cytochrome oxidase activity and two maternally related Scottish patients from a family with suspected maternal inheritance of the disease. We found five substitutions in coding regions that have not previously been described as polymorphisms. These new substitutions were studied in 81 schizophrenic patients and five control groups from Sweden and Scotland and found to differ in frequency between populations, emphasizing the importance of using large and well-defined control materials for evaluating the association of mtDNA mutations with disease. The results do not lend strong support to the association of a particular mtDNA substitution with increased risk for schizophrenia. However, the trend towards a higher frequency of substitutions in the patients deserves further attention.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
DNA Mitocondrial
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article