Distribution of progesterone receptor in chicken: novel target organs for progesterone and estrogen action.
Mol Cell Endocrinol
; 135(1): 79-91, 1997 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-9453243
ABSTRACT
Expression of progesterone receptor (PR) in various organs of sexually immature chickens and after estrogen treatment was studied by immunohistochemical and Western blotting analyses. Constitutive PR expression was observed in the mesothelium and stroma of the esophagus, proventriculus, liver, spleen, pancreas, heart and lung. In the urogenital tract, PR was expressed in the mesothelial and stromal cells and smooth muscle of blood vessels. Estrogen treatment induced PR expression in the stroma and smooth muscle of the gall bladder and in the epithelium and stroma of the trachea. In the ovary of immature chickens PR was localized in the epithelium, stroma and smooth muscle and was induced in the granulosal cells by estrogen. In most tissues there was more PR-B than PR-A expression and this PR-B dominance remained after estrogen treatment. These results suggest that progesterone and estrogen may have physiological effects on many organs outside the genital tract not previously known as steroid-target tissues.
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Base de dados:
MEDLINE
Assunto principal:
Especificidade de Órgãos
/
Progesterona
/
Receptores de Progesterona
/
Estrogênios
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article