Serologic association of human herpesvirus eight with posttransplant Kaposi's sarcoma in Saudi Arabia.
Transplantation
; 65(4): 583-5, 1998 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-9500639
ABSTRACT
PIP: In Saudi Arabia, Kaposi's sarcoma occurs in 4.1% of renal transplant recipients and accounts for 70% of malignancies in this group. Human herpes virus 8 (HHV8) has been identified in the DNA of many of these patients. The association between HHV8 and Kaposi's sarcoma was investigated further in post-renal transplant Kaposi's sarcoma patients from a tertiary care hospital (King Faisal Specialist Hospital and Research Center) in Riyadh, Saudi Arabia (n = 14), and non-Kaposi's sarcoma controls with renal transplant (n = 18), chronic renal failure (n = 14), other cancers that did not affect renal function (n = 15), and healthy volunteers (n = 15). The median time from transplant to Kaposi's sarcoma was 13 months. A serum sample was assumed to have antibodies to HHV8 if antibody to either p40 or sVCA was detected. The prevalence of HHV8 seroreactivity was 13/14 (93%) in cases, 5/18 (28%) in renal transplants without Kaposi's sarcoma, and 11/62 (18%) in the aggregate control group. HHV8 seroreactivity was significantly more common (p 0.001) among transplant patients with Kaposi's sarcoma than those without this cancer (odds ratio, 33.80; 95% confidence interval, 2.96-904). These findings suggest an etiologic link between HHV8 and Kaposi's sarcoma presumably due to immunologic or cellular factors that influence host-virus interactions.
Palavras-chave
Arab Countries; Asia; Biology; Cancer; Comparative Studies; Developing Countries; Diseases; Immunity; Immunologic Factors; Neoplasms; Physiology; Renal Effects; Research Methodology; Research Report; Risk Factors; Saudi Arabia; Studies; Urogenital Effects; Urogenital System; Viral Diseases; Western Asia
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Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Sarcoma de Kaposi
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Transplante de Rim
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Herpesvirus Humano 8
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article