Effect of ranitidine on gastric intramucosal pH in critically ill patients.
Intensive Care Med
; 24(1): 12-7, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9503217
ABSTRACT
OBJECTIVE:
To determine whether ranitidine a) increases the values of gastric intramucosal pH (pHi) in critically ill patients, as determined by tonometry; b) reduces the variability of these measurements.DESIGN:
Prospective, double blind, randomized, placebo-controlled study.SETTING:
General Intensive Care Unit of a teaching hospital. PATIENTS Twenty-five critically ill, mechanically ventilated patients requiring arterial catheter and nasogastric tube.INTERVENTIONS:
Tonometer placement; blind, random administration of intravenous ranitidine (50 mg) or placebo. MEASUREMENTS AND MAINRESULTS:
Tonometer saline PCO2 (PCO2i), arterial blood gases, gastric juice pH and pHi were determined immediately before, and 2, 4, 6 and 8 h after, ranitidine (12 patients) or placebo (13 patients). Ranitidine significantly increased gastric juice pH, but did not affect PCO2i or pHi; pHi was 7.34 +/- 0.14 before ranitidine, and 7.30 +/- 0.12, 7.31 +/- 0.11, 7.31 +/- 0.14 and 7.31 +/- 0.12-2, 4, 6 and 8 h, respectively, after ranitidine administration (p = 0.55). Ranitidine did not modify the coefficients of variation of PCO2i or pHi, either. No significant changes in gastric juice pH, PCO2i or pHi were observed in the placebo group.CONCLUSIONS:
In critically ill patients, ranitidine has no effect on pHi values, and does not increase the reproducibility of pHi measurements.
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Base de dados:
MEDLINE
Assunto principal:
Ranitidina
/
Estado Terminal
/
Mucosa Gástrica
/
Antagonistas dos Receptores H2 da Histamina
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article